February 15, 2005
Lei Sun, Kenneth Wilder, Mary Sara McPeek
The following files describe the usage, input and output of
our PREST and ALTERTEST software.
PREST is a program that detects pedigree errors by use of
PREST incorporates the EIBD, AIBS, IBS, and MLLR test statistics
developed by McPeek and Sun (2000),
Statistical Tests for Detection of Misspecified Relationships
by Use of Genome-Screen Data,
American Journal of Human Genetics 66:1076-1094.
ALTERTEST is a program that performs the EIBD, AIBS, IBS and
MLLR tests on the problematic relative pairs identified using
PREST. The purpose of ALTERTEST is to allow the user to choose
the relationship to be used as the null hypothesis for the tests,
and this relationship is allowed to be different from that given
by the pedigree. In contrast, PREST will automatically use the
relationship specified by the pedigree as the null hypothesis
for the tests. ALTERTEST can be used independently of PREST.
The current PREST distribution includes an R program written by
Daniel E. Weeks (firstname.lastname@example.org) that draws out the
the sharing probabilities on the 'relationship triangle' as described in
Elizabeth Thompson's book "Pedigree Analysis in Human Genetics".
About Weeks's R Program