GKW.test is a R function that implements the the Generalized Kruskal-Wallis test proposed to incorporate group uncertainty into the classical rank-based test (Acar and Sun, 2010). The extended test statistic is based on probability-weighted rank-sums and follows an asymptotic chi-square distribution with k-1 degrees of freedom under the null hypothesis.

The work here was originally motivated by the analysis of imputed SNPs in genome-wide association studies (GWAS), application of the proposed method however is not limited to this type data, suitable for analyses of other genetic markers including variants identified in the next-generation sequencing (NGS) experiments, and goes beyond studies of genetic data.

Contact: Elif Fidan Acar, elif at utstat at toronto at edu or Lei Sun, sun at utstat at toronto at edu